The Nobel Prize in Chemistry 2022 has been awarded to three academic pioneers of click chemistry and bioorthogonal chemistry: previous winner K. Barry Sharpless of Scripps Research; Morten Meldal of the University of Copenhagen: and Carolyn R. Bertozzi of Stanford University. “Sometimes simple answers are the best,” said the committee awarding the prize. “Click chemistry and bioorthogonal reactions have taken chemistry into the era of functionalism” and “this is bringing the greatest benefit to humankind.”