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New ADC technology from Merck KGaA

Merck KGaA’s Life Science business sector has launched ChetoSensar, a technology that improves the solubility of antibody-drug conjugates (ADCs). Over 20% of ADC candidates are terminated in clinical trials because of poor solubility. The company said that this supports it efforts to double its ADC and HPAPI capacity in the near future.

Merck announces ADC/HPAPI expansion

Merck KGaA is to spend €59 million to expand HPAPI and ADC manufacturing capabilities and capacity at its facility near Madison, Wisconsin. Completion is expected by mid-2022 and should add approximately 50 full-time jobs from 2021.

The investment will allow large-scale manufacturing of highly potent oncology compounds, the company said. The 6,500 m2 building will be one of the largest dedicated HPAPI facilities specifically designed to handle single-digit nanogram OEL materials.

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