CDMO Curia is to collaborate with Corning’s Advanced-Flow Reactor (AFR) team to expand and accelerate continuous flow development and manufacturing for the chemical and biopharmaceutical industries. This includes installing Corning’s G1 production system (pictured), designed for the continuous industrial production of APIs at Curia’s Albany facility.
Under a newly signed partnership, AGC Pharma Chemicals and CatSci will combine to offer the former’s expertise in GMP manufacturing from development and manufacturing through to commercial with the latter’s in chemical development, analytical development, crystallisation and solid form, pre-formulation and HPAPI capabilities.
Following two years of construction work, CDMO Siegfried has officially opened its new development centre for drug products at its sites in Barberà del Vallès and El Masnou near Barcelona. About 40 specialist scientists will work there.
The centre features laboratories and pilot capacities, including dedicated facilities for highly potent oral solid dosage forms. Siegfried said that the opening also completes the successful integration of the two sites into its network. It originally acquired them from Novartis in 2020.
Bachem has signed a new framework agreement to provide large volumes of peptides to an unnamed customer following a joint development project. This covers “a committed volume at an equivalent value of over CHF 500 million for the five-year period of 2027-2031, with significant upside potential,” the company said.
This follows recent deals a previous large-volume contract for another unnamed customer worth CHF 175 million in 2023-4. The deal was announced in September 2022 and subsequently upgraded with a further work order for a minimum total of CHF 1 billion from 2025 to 2029.
During the recent BioProcess International US West conference in San Diego, Spectrum Chemical announced an expansion of its BioCertified line of products that undergo complete lot analysis including expanded testing for endotoxin, bioburden and elemental impurities.
This brings the total in the BioCertified range to about 100. The new products include:
* An expanded line of biological buffers, which are used in modelling biological systems, cell culture, bioprocessing, purification and formulation
* Amino acids for protein purification and formulations
Nippon Shokubai has concluded a licence agreement with its Japanese compatriot and affiliate company, Rena Therapeutics, to make and sell heteroduplex oligonucleotide (HDO) as a research reagent to industry and academia in all countries where it is covered by patents. Rena has existing licences with Ionis Pharmaceuticals and Takeda Pharmaceutical.
Piramal Pharma Solutions has begun production of initial batches of APIs in new reactor suites at its facility in Riverview, Michigan. This, the company said, represent the first in a three-step process for the development and manufacturing of Phase II clinical trial materials. As part of the programme, technicians are scaling up material from 10-15 kg to 75-80 kg.
