Following on from the extension of a long-standing supply agreement with Merck & Co. for a proprietary enzyme used in the manufacture of sitagliptin, Codexis has reached a manufacturing agreement with two other firms. Sitagliptin is the API in Merck’s Januvia and one of the APIs in Janumet.
The European Commission (EC) has fined Sigma-Aldrich €7.5 million for three infringements in providing incorrect or misleading information in its replies to two requests for information made pursuant to Article 11(2) of the EU Merger Regulation during the official investigation into its acquisition by Merck KGaA in 2015.
Merck KGaA is to spend €59 million to expand HPAPI and ADC manufacturing capabilities and capacity at its facility near Madison, Wisconsin. Completion is expected by mid-2022 and should add approximately 50 full-time jobs from 2021.
The investment will allow large-scale manufacturing of highly potent oncology compounds, the company said. The 6,500 m2 building will be one of the largest dedicated HPAPI facilities specifically designed to handle single-digit nanogram OEL materials.
Azelis has concluded a new agreement with Merck KGaA, covering the distribution of Merck Performance Materials’ complete range in Vietnam for personal care, CASE, food and health, and industrial chemicals. The division’s products include pigments, active ingredients and raw materials. The two companies have been partners since 1968 and have existing distribution relationships in Europe and other regions.